ISMMS - Institut des Sciences du Mouvement et de la Médecine du sport

• Etudes de Médecine à l'Université d'Amsterdam (MD 1986) et Doctorat en physiologie de l'effort à l'Université libre d'Amsterdam (PhD 1994)
• Etudes postdoctorales à l'Université McGill à Montréal Canada
• Depuis 2002 professeur à la faculté de médecine de l'Université de Genève
• Recherche: méchanismes de limitation de l'effort en endurance, effects d'hyoxie et altitude, échanges gazeux, relation entre activité physique et santé, dopage.

Publication récentes:

Physiologie de l'exercice
Physiologie et médecine de l'altitude
Dopage
Activité physique et santé
Activité physique et maladies chroniques
Activité physique et alimentation

Physiologie de l'exercice

• Fan JL, Leiggener C, Rey F, Kayser B. Effect of inspired CO₂ on the ventilatory response to high intensity exercise. Respir Physiol Neurobiol. 2012 Mar 15;180(2-3):283-8.
• Woorons X, Bourdillon N, Lamberto C, Vandewalle H, Richalet JP, Mollard P, Pichon A. Cardiovascular responses during hypoventilation at exercise. Int J Sports Med, 32: 438-445, 2011.
• Fan JL, Burgess KR, Thomas KN, Peebles K, Lucas SJE, Lucas RAI, Cotter JD, Ainslie PN. Influence of indomethacin on the ventilatory and cerebrovascular responsiveness to hypoxia. The European Journal of Applied Physiology, 111: 601-610, 2011.
• Subudhi AW, Olin JT, Dimmen AC, Polaner DM, Kayser B, Roach RC. Does cerebral oxygen delivery limit incremental exercise performance? J Appl Physiol. 2011 Dec;111(6):1727-34.
• Neyroud D, Maffiuletti NA, Kayser B, Place N. Mechanisms of Fatigue and Task Failure Induced By Sustained Submaximal Contractions. Med Sci Sports Exerc. 2011 Dec 30.
• Fares EJ, Kayser B. Carbohydrate mouth rinse effects on exercise capacity in pre- and postprandial States. J Nutr Metab. 2011;2011:385962.
• Wac K, Hausmann J, Kayser B. How to keep track of one's physical activity budget using pervasive technologies. J Appl Physiol. 2011 Aug;111(2):611-2; discussion 614. No abstract available.
• Mollard P, Bourdillon N, Letournel M, Herman H, Gibert S, Pichon A, Woorons X, and Richalet JP. Validity of arterialized earlobe blood gases at rest and exercise in normoxia and hypoxia. Respir Physiol Neurobiol 172: 179-183, 2010.
• Woorons X, Bourdillon N, Vandewalle H, Lamberto C, Mollard P, Richalet JP, and Pichon A. Exercise with hypoventilation and muscle oxygenation: role of hypoxia and hypercapnia. Eur J Appl Physiol 110: 367-377, 2010.
• Kayser B. Danes with brains. J Physiol. 2010 Jul;588(Pt 13):2285. No abstract available.
• Fan JL, Burgess KR, Thomas KN, Peebles K, Lucas SJE, Lucas RAI, Cotter JD, Ainslie PN. IInfluence of indomethacin on ventilatory and cerebrovascular responsiveness to CO2; comparison between steady-state and modified rebreathing. America Journal of Physiology; Regulatory, Comparative and Integrative Physiology. 2010 Jun; 298(6):R1648-58.
• Wilson LC, Cotter JD, Fan JL, Lucas RAI, Thomas KN, Ainslie PN. Cerebrovascular reactivity and dynamic autoregulation in tetraplegia. American Journal of Physiology; Regulatory, Comparative and Integrative Physiology. 2010 Apr;298(4):R1035-42.
• Burgess KR, Fan JL, Thomas KN, Lucas SJE, Peebles K, Dawson A, Swart M, Bilson K, Ainslie PN. Exacerbation of obstructive sleep apnea by oral indomethacin. Chest. 2010 Mar;137(3):707-10.
• Place N, Kayser B. Limitation of performance and the brain: simply more complex. J Appl Physiol. 2010 Feb;108(2):463;author reply 469. No abstract available.
• Bourdillon N, Mollard P, Letournel M, Beaudry M, and Richalet JP. Interaction between hypoxia and training on NIRS signal during exercise: Contribution of a mathematical model. Respir Physiol Neurobiol 169: 50-61, 2009.
• Bourdillon N, Mollard P, Letournel M, Beaudry M, and Richalet JP. Non-invasive evaluation of the capillary recruitment in the human muscle during exercise in hypoxia. Respir Physiol Neurobiol 165: 237-244, 2009.
• Lucas RAI, Ainslie PN, Fan JL, Wilson LC, Thomas KN, Cotter JD. Skin cooling aids cardiovascular and cerebrovascular function under severe but not moderate heat stress, independent of hydration state. European Journal of Applied Physiology. 2009 Nov; 109 (1):101-8.
• Aliverti A, Kayser B, Cautero M, Dellacà RL, di Prampero PE, Capelli C. Pulmonary V(O)(2) kinetics at the onset of exercise is faster when actual changes in alveolar O2 stores are considered. Respir Physiol Neurobiol. 2009 Oct 31;169(1):78-82.
• Wüst RC, Aliverti A, Capelli C, Kayser B. Breath-by-breath changes of lung oxygen stores at rest and during exercise in humans. Respir Physiol Neurobiol. 2008 Dec 31;164(3):291-9.
• Fan JL, Cotter JD, Lucas RA, Thomas KN, Wilson LC, Ainslie PN. Human cardiorespiratory and cerebrovascular function during severe passive hyperthermia: effects of mild hypohydration. Journal of Applied Physiology. 2008 Aug;105(2):433-45.
• Fudge BW, Easton C, Kingsmore D, Kiplamai FK, Onywera VO, Westerterp KR, Kayser B, Noakes TD, Pitsiladis YP. Elite Kenyan endurance runners are hydrated day-to-day with ad libitum fluid intake. Med Sci Sports Exerc. 2008 Jun;40(6):1171-9.
• Tucker R, Kayser B, Rae E, Raunch L, Bosch A, Noakes T. Hyperoxia improves 20 km cyclingtime trial performance by increasing muscle activation levels while perceived exertion stays the same. Eur J Appl Physiol. 2007 Dec;101(6):771-81.
• Dumas JL, Pichon A, Bourdillon N, Augier A, Richalet JP, and Lamberto C. Functionnal anatomy of motor cortex in hypoxic conditions : a feasibility study. [French]. Morphologie 91(293) : 100-106, 2007.
• Fudge BW, Wilson J, Easton C, Irwin L, Clark J, Haddow O, Kayser B, Pitsiladis YP. Estimation of oxygen uptake during fast running using accelerometry and heart rate. Med Sci Sports Exerc. 2007 Jan;39(1):192-8.

Physiologie et médecine de l'altitude

• Fan JL, Burgess KR, Thomas KN, Lucas SJ, Cotter JD, Kayser B, Peebles KC, Ainslie PN. Effects of acetazolamide on cerebrovascular function and breathing stability at 5050 m.J Physiol. 2012 Mar 1;590(Pt 5):1213-25.
• Lucas SJ, Burgess KR, Thomas KN, Donnelly J, Peebles KC, Lucas RA, Fan JL, Basnyat R, Cotter JD, Ainslie PN. Alterations in cerebral blood flow and cerebrovascular reactivity during 14 days at 5050 m. Journal of Physiology. In press.
•  Wu TY, Ding SQ, Zhang SL, Duan JQ, Li BY, Zhan ZY, Wu QL, Baomu S, Liang BZ, Han SR, Jie YL, Li G, Sun L, Kayser B. Altitude illness in Qinghai–Tibet railroad passengers. High Alt Med Biol. 2010 Fall;11(3):189-98.
• Wu T, Ding S, Kayser B. Work at high altitude after coronary stenting: safe? Wilderness Environ Med. 2010 Mar;21(1):86-7
• Fan JL, Burgess KR, Basnyat R, Thomas KN, Peebles K, Lucas SJE, Lucas RAI, Cotter JD, Ainslie PN. Influence of high altitude on cerebrovascular and ventilatory responsiveness to CO2. Journal of Physiology. 2010 Feb 1; 588(Pt 3):539-49.
• Wu TY, Ding SQ, Zhang SL, Duan JQ, Li BY, Zhan ZY, Wu QL,Baomu S, Liang BZ, Han SR, Jie YL, Li G, Sun L, Kayser B. Altitude illness in Qinghai-Tibet railroad passengers. High Alt Med Biol. 2010 Fall;11(3):189-98.
• Thomas KN, Burgess KR, Basnyat R, Lucas SJ, Cotter JD, Fan JL, Peebles KC, Lucas RA, Ainslie PN. Initial orthostatic hypotension at high altitude. High Altitude Medicine and Biology. 2010 Summer;11(2):163-7.
• Wu T, Ding S, Kayser B. Work at high altitude after coronary stenting: safe? Wilderness Environ Med. 2010 Mar; 21(1):86-7. No abstract available.
• Kayser B, Aliverti A, Pellegrino R, Dellaca R, Quarata M, Pompilio P, Miserocchi G, Cogo A. Comparison of visual analogue scale and Lake Louise symtom scores for acute mountain sickness. High alt Med Biol. 2010 Spring; 11(1):69-72.
• Pellegrino RG, Pompilio PP, Quaranta M, Aliveri A, Kayser B, Miserocchi GA, Fasano V, Cogo A, Milanese M, Cornara G, Brusasco V, Dellaca RL. Airway reponses to methacholine and exercice at high altitude in healthy lowlanders..J Appl Physiol. 2010 Apr;108(4):765-6.
• Kayser B. Disentangling hypoxia and hypobaria.Respir Physiol Neurobiol 169: 50-61, 2009.
• Wu TY, Ding SQ, Liu JL, Yu MT, Jia JH, Duan JQ, Chai ZC, Dai RC, Zhang SL, Liang BZ, Zhao JZ, Qi de T, Sun YF, Kayser B. Reduced incidence and severity of acute mountain sickness in Qinghai-Tibet railroad construction workers after repeated 7-month exposures despite 5-month low altitude periodes. High Alt Med Biol. 2009 Fall;10(3):221-32.
• Amann M, Kayser B. Nervous system function during exercise in hypoxia. High Alt Med Biol. 2009 Summer; 10(2):149-64.
• Kayser B. J Appl P. Blood lactate at high altitude: central command but also mass effect and andrenergic drive. hysiol. 2009 Feb; 106(2):739. No abstract available.
• Berendsen RR, Willems JH, Bosch FH, Hulsebosch R, Kayser B. [ Serious and sometimes fatal consequences of high-altitude pulmonary oedema] Ned Tijdschr Geneeskd. 2008 Dec 20;152 (51-52):2758-62. (article in Dutch).
• Kayser B, Hulsebosch R, Bosch F. Low-dose acetylsalicylic acid analog and acetazolamide for prevention of acute mountain sickness. High Alt Med Biol. 2008 Spring;9(1):15-23.
• Dellasanta P, Gaillard S, Loutan L, Kayser B. Comparing questionnaires for the assessment of ac u te mountain sickness. High Alt Med Biol. 2007 Fall; 8 (3): 184-91.
• Roach R, Kayser B. Measuring mountain maladies. High Alt Med Biol. 2007 Fall;8(3):171-72./li>
• Wu TY, Ding SQ, Liu JL, Yu MT, Jia JH, Chai ZC, Dai RC, Zhang SL, Li BY, Pan L, Liang BZ, Zhao JZ, Qi de T, Sun YF, Kayser B. Who should not go high: chronic disease and work at altitude during construction of the Qinghai-Tibet railroad. High Alt Med Biol. 2007 Summer;8(2):88-107.
• Grassi B, Marzorati M, Kayser B, Marconi C, Cerretelli P. Comments on point:counterpoint: "the lactate paradox does/does not occur during exercise at high altitude". J Appl Physiol. 2007 Jun;102(6):2404-5.

Dopage

• Kayser B. Comments on Lundby et al.'s “testing for recombinant human erythropoietin in urine: problems associated with current anti-doping testing“ J Appl Physiol. 2008 Dec; 105(6):1993; author reply 1997-8. No abstract available.
• Kayser B, Smith AC. Globalisation of anti-doping: the reverse side of the medal. BMJ. 2008 Jul 4;337:a584.
• Lippi G, Franchini M, Kayser B. Comment to: Recombinant erythropoietin found in seized blood bags from sportsmen. Haematologica 2008;93:313- 4.Haematologica. 2008 Jul;93(7):e55; author reply e 56.
• Kayser B, Mauron A, Miah A. Current anti-doping policy: a critical appraisal. BMC Med Ethics. 2007 Mar 29;8:2

Activité physique et santé

• Melzer K, Schutz Y, Kayser B. Normalization of basal metabolic rate for differences in body weight in pregnant women. Eur J Obstet Gynecol Reprod Biol. 2011 Dec;159(2):480-1. No abstract available.
• Genton L, Melzer K, Pichard C. Energy and macronutrient requirements for physical fitness in exercising subjects. Clin Nutr. 2010 Aug;29(4):413-23.
• Melzer K, Schutz Y. Pre-pregnancy and pregnancy predictors of obesity. Int J Obes (Lond). 2010 Dec;34(S2):S44-S52.
• Melzer K, Schutz Y, Soehnchen N, Othenin Girard V, Martinez de Tejada B, Pichard C, Irion O, Boulvain M, Kayser B. Pre-pregnancy Body Mass Index and Resting Metabolic Rate during Pregnancy. Ann Nutr Metab. 2010 Dec 2;57(3-4):221-227.
• Kayser B, Kossovsky MP, Sigaud P, Carballo D, Keller PF, Martin XE, Farpour-Lambert N, Pichard C, Mach F. Stairs instead of elevators at workplace: cardioprotective effects of a pragmatic intervention. Eur J Cardiovasc Prev Rehabil. 2010 Oct;17(5):569-75
• Melzer K, Schutz Y, Boulvain M, Kayser B. Physical activity and pregnancy: cardiovascular adaptations, recommendations and pregnancy outcomes. Sports Med. 2010 Jun1;40(6):493-507 (Review).
• Melzer K, Schutz Y, Soehnchen N, Othenin-Girard V, Martinez de Tejada B, Irion O, Boulvain M, Kayser B. Effects of recommended levels of physical activity on pregnancy outcomes. Am J Obstet Gynecol. 2010 Mar;202(3):266.e1-6.
• Meyer P, Kayser B, Mach F. Stair use for cardiovascular disease prevention. Eur J Cardiovasc Prev Rehabil. 2009 Aug;16 Suppl 2:S17-8.
• Melzer K, Schutz Y, Boulvain M, Kayser B. Pregnancy-related changes in activity energy expenditure and resting metabolic rate in Switzerland. Eur J Clin Nutr. 2009 Oct;63(10):1185-91
• Kayser B. Determinants of active commuting. Prev Med. 2008 Jan;46(1):8.
• Melzer K, Laurie Karsegard V, Genton L, Kossovsky MP, Kayser B, Pichard C. Comparison of predictive equations for estimating resting metabolic rate in healthy subjects over 70 years of age Clin Nutr. 2007 Aug;26(4):498-505.
• Kyle UG, Melzer K, Kayser B, Picard-Kossovsky M, Gremion G, Pichard C. Eight-year longitudinal changes in body composition in healthy Swiss adults. J Am Coll Nutr. 2006 Dec;25(6):493-501.
• Melzer K, Kayser B, Saris WH, Pichard C. Effects of physical activity on food intake. Clin Nutr. 2005 Dec;24(6):885-95.
• Melzer K, Kayser B, Pichard C. Physical activity: the health benefits outweigh the risks. Curr Opin Clin Nutr Metab Care. 2004 Nov;7(6):641-7.

Activité physique et maladies chroniques

• Aliverti A, Kayser B, Macklem PT. A human model of the pathophysiology of chronic obstrutive pulmonary disease. Respirology. 2007 Jul;12(4):478-85.

Activité physique et alimentation

•  Melzer K. Carbohydrate and fat utilization during rest and physical activity.e-spen, the European e-journal of clinical Nutrition and Métabolism (2011), doi:10.1016/j.eclnm.2011.01.005
• Melzer K, Kayser B, Saris WH, Pichard C. Effects of physical activity on food intake. Clin Nutr. 2005 Dec;24(6):885-95.